HIGH POINT, N.C., March 21, 2014 – High Point University associate professor of physiology Dr. James Smoliga recently published his research on the development of a resveratrol lozenge in the peer reviewed journal, “PLOS One.”

Resveratrol is an anti-oxidant found in red wine and is believed to be responsible for the cardiovascular benefits of red wine. In the research, Smoliga, along with researchers at Wilmore Labs and the University of Texas Health Science Center at San Antonio, found by dissolving resveratrol in sugars, the anti-oxidant could be administered to the blood stream through a lozenge.

“From this, we can perform larger studies exploring the use of resveratrol lozenges,” says Smoliga. “Resveratrol pills are sometimes, though not always, reported to have side effects on the GI tract, so this lozenge can hopefully eliminate that. Additionally, the lozenge allows resveratrol to get into the system very rapidly, which may expand the clinical applications it can be used for.”

An online version of the article can be found here: http://dx.plos.org/10.1371/journal.pone.0090131

resveratrol – Google News


  Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target?

Through their pleiotropic actions, statins, fibrates, thiazolidinediones and resveratrol can target multiple mechanisms involved in sepsis. Their actions on mitochondrial function are of interest in a pathological state where bioenergetic failure may play a key role in the development of organ dysfunction.

We review these four drug groups as potential adjunctive therapies in sepsis with a particular focus upon mitochondria. Systematic review of clinical and experimental trials was done with a literature search using the PubMed database.

Search terms included statins, fibrates, thiazolidinediones, resveratrol, mitochondria, sepsis, peroxisome proliferator-activated receptors, inflammation, oxidative stress and organ dysfunction. With the exception of statins, most of the compelling evidence for the use of these agents in sepsis comes from the experimental literature.

The agents all exert anti-inflammatory and anti-oxidant properties, plus protective effects against mitochondrial dysfunction and stimulation of mitochondrial biogenesis. Improved outcomes (organ dysfunction, survival) have been reported in a variety of sepsis models.

Notably, positive outcome effects were more commonly seen when the agents were given as pre- rather than post-treatment of sepsis. Statins, fibrates, thiazolidinediones and resveratrol prevent sepsis-induced injury to organs and organelles with outcome improvements.

Their effects on mitochondrial function may be integral in offering this protection. Definitive clinical trials are needed to evaluate their utility in septic patients or those at high risk of developing sepsis.

Author: Jerome MorelMervyn Singer
Credits/Source: Intensive Care Medicine Experimental 2014, 2:9

Published on: 2014-04-17

News Provider: 7thSpace Interactive

Copyright by the authors listed above – made available via BioMedCentral (Open Access). Please make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.

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resveratrol – Google News


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