HIGH POINT, N.C., March 21, 2014 – High Point University associate professor of physiology Dr. James Smoliga recently published his research on the development of a resveratrol lozenge in the peer reviewed journal, “PLOS One.”

Resveratrol is an anti-oxidant found in red wine and is believed to be responsible for the cardiovascular benefits of red wine. In the research, Smoliga, along with researchers at Wilmore Labs and the University of Texas Health Science Center at San Antonio, found by dissolving resveratrol in sugars, the anti-oxidant could be administered to the blood stream through a lozenge.

“From this, we can perform larger studies exploring the use of resveratrol lozenges,” says Smoliga. “Resveratrol pills are sometimes, though not always, reported to have side effects on the GI tract, so this lozenge can hopefully eliminate that. Additionally, the lozenge allows resveratrol to get into the system very rapidly, which may expand the clinical applications it can be used for.”

An online version of the article can be found here: http://dx.plos.org/10.1371/journal.pone.0090131


resveratrol – Google News

{ 0 comments }

  Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target?

Through their pleiotropic actions, statins, fibrates, thiazolidinediones and resveratrol can target multiple mechanisms involved in sepsis. Their actions on mitochondrial function are of interest in a pathological state where bioenergetic failure may play a key role in the development of organ dysfunction.

We review these four drug groups as potential adjunctive therapies in sepsis with a particular focus upon mitochondria. Systematic review of clinical and experimental trials was done with a literature search using the PubMed database.

Search terms included statins, fibrates, thiazolidinediones, resveratrol, mitochondria, sepsis, peroxisome proliferator-activated receptors, inflammation, oxidative stress and organ dysfunction. With the exception of statins, most of the compelling evidence for the use of these agents in sepsis comes from the experimental literature.

The agents all exert anti-inflammatory and anti-oxidant properties, plus protective effects against mitochondrial dysfunction and stimulation of mitochondrial biogenesis. Improved outcomes (organ dysfunction, survival) have been reported in a variety of sepsis models.

Notably, positive outcome effects were more commonly seen when the agents were given as pre- rather than post-treatment of sepsis. Statins, fibrates, thiazolidinediones and resveratrol prevent sepsis-induced injury to organs and organelles with outcome improvements.

Their effects on mitochondrial function may be integral in offering this protection. Definitive clinical trials are needed to evaluate their utility in septic patients or those at high risk of developing sepsis.

Author: Jerome MorelMervyn Singer
Credits/Source: Intensive Care Medicine Experimental 2014, 2:9

Published on: 2014-04-17

News Provider: 7thSpace Interactive

Copyright by the authors listed above – made available via BioMedCentral (Open Access). Please make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here.


Social Bookmarking
RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo

Comments


Google

Custom Search



resveratrol – Google News

{ 0 comments }

SkinStore.com Announces the Addition of SkinCeuticals Resveratrol B E – PR Web (press release)

April 14, 2014

Gold River, CA (PRWEB) March 19, 2014 SkinStore.com, the nation’s leading e-commerce specialty retailer with over 9000 products for healing and maintaining healthy skin, has added SkinCeuticals Resveratrol B E to its assortment of premium products. Between aging and environmental factors like pollution and UV rays, the skin loses the ability to effectively repair and [...]

Read the full article →

@^^/@@ Cialis in canada – BayJournal (press release)

April 13, 2014

Sharma P, and this includes pregnancy, please see our Comment Posting Guidelines, and should take adequate vitamin D and calcium supplementation, working at an independent is a great trade off, diagnosis and classification of diabetes mellitus and its complications, wipe it with bath salts are often overworked. Polycystic Ovary Syndrome is the most common hormonal [...]

Read the full article →

Conformational changes and translocation of tissue-transglutaminase to the … – 7thSpace Interactive (press release)

April 12, 2014

  Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In present study, we explored the mechanism of how TG2 may be involved in [...]

Read the full article →

What you need to know about radiation when you fly – MyFox Detroit

April 9, 2014

By: Dr. Joel Kahn Maybe your business requires you to travel cross-country to consult.Perhaps you have an aging relative who lives far away and you fly frequently to see her.Or maybe you get a true vacation like the one I am on today, visiting Prague with a daughter who is studying abroad. Flying may bring [...]

Read the full article →

Geneticist upbeat about fight against aging – Omaha World-Herald

April 5, 2014

Tequila ingredient aids in weight loss, study says At a recent meeting of the American Chemical Society, a study was presented that shows that agavin, a sweetener created from the same plant used to make tequila, possesses a number of health benefits resveratrol – Google News

Read the full article →

LYCOTEC TURNS RED WINE TO MEDICINE. Unique Resveratrol formulation … – SourceWire (press release)

March 19, 2014

The French Paradox is a phenomenon that people in France, who have highest consumption of red wine per person, have the lowest cardiovascular mortality rate and one of the longest in longevity in the Western world. One of the key molecules behind this is a grape flavonoid molecule trans-Resveratrol, t-RSV. Numerous experimental laboratory studies of [...]

Read the full article →

Compound That May Mimic Calorie Restriction Extends Life Span in Mice – Scientific American

March 18, 2014

YES! Send me a free issue of Scientific American with no obligation to continue the subscription. If I like it, I will be billed for the one-year subscription. Scientific American is a trademark of Scientific American, Inc., used with permission © 2014 Scientific American, a Division of Nature America, Inc. View Mobile Site All Rights [...]

Read the full article →

Superfood in Berries Promotes Weight Loss and Younger Skin – Yahoo Lifestyle UK

March 18, 2014

This powerful ingredient really is the ultimate anti-ager.Science shows that resveratrol is pushing its way to the top of the buzz-worthy ingredient list. It’s been shown to help treat everything from heart disease to diabetes as well as naturally turn back the clock on skin. Here’s why you’ll want to harness resveratrol’s impressive health and [...]

Read the full article →